Irritable Bowel Syndrome (IBS)
If you suffer from the following ongoing symptoms, you might have IBS:
IBS is a chronic, often debilitating, functional gastrointestinal disorder with symptoms that include abdominal pain, bloating, and altered bowel behaviours. These are constipation and/or diarrhea, or alternating between the two stool consistency extremes. IBS is a functional disorder, in that the function or movement of the bowel is not quite right. There are no medical tests to confirm or rule out a diagnosis and yet it is the most common gastrointestinal condition worldwide and the most common disorder presented by patients consulting a gastrointestinal specialist (gastroenterologist).
IBS affects an estimated 13-20% of Canadians at any given time, depending on which criteria researchers use to assess symptoms. The lifetime risk for a Canadian to develop IBS is 30%.
IBS can begin in childhood, adolescence, or adulthood and can resolve unexpectedly for periods throughout an individual’s lifespan, recurring at any age. In Canada and most Western nations, IBS seems to arise significantly more frequently in women than in men, but the reason for this remains unclear.
Although each person can have a unique IBS experience within the range of known symptoms, this condition typically decreases a person’s quality of life. Interestingly, only about 40% of those who have IBS symptoms seek help from a physician.
Over the years, some have called this collection of symptoms by many names, including mucous colitis, nervous colon, spastic colon, and irritable colon, but these are all misleading, mostly because IBS is not limited to the large intestine (colon). Sometimes, IBS is confused with colitis or other inflammatory diseases of the intestinal tract, but the difference is clear – in IBS, inflammation or infection is not evident.
30-Second IBS Test
Please take this test to see if you might have Irritable Bowel Syndrome (IBS)
Almost every human being has experienced abdominal cramping, bloating, constipation, or diarrhea at some point in his or her life. However, those who have IBS experience these multiple symptoms more frequently and intensely, to the extent that they interfere with day-to-day living.
A person who has IBS is likely to have a sensitive digestive system with heightened reactivity, so that the bowel responds quite differently to normal gut stimuli, such as the passage of solids, gas, and fluid through the intestines. These unusual movements may result in difficulty passing stool, or sudden, urgent elimination. Up to 20% of those who have IBS report untimely passage of stool. Some individuals with IBS may also experience straining to pass stool along with a feeling of incomplete evacuation (tenesmus) and immense relief of pain/discomfort when gas or stool finally passes. A stringy substance (mucus) may cover the stool.
Individuals could have different combinations of symptoms, with one being predominant, while others have more random and unpredictable digestive symptoms. These altering bowel experiences and their unpredictability can lead to a high degree of anxiety for the IBS patient. Stool consistency may vary enormously, ranging from entirely liquid to so firm and separated that it resembles small pebbles. External factors, such as stress, can affect stool consistency. IBS is often broken down into different sub-groups, which are associated with stool consistency.
- IBS-D is when the digestive system contracts quickly, transiting products of digestion rapidly through the digestive tract, resulting in frequent, watery bowel movements (diarrhea).
- IBS-C is when the digestive system contracts slowly, delaying transit time for products of digestion, resulting in hard, difficult to pass, infrequent stools (constipation).
- IBS-A is when the transit time throughout the digestive tract fluctuates and stools may alternate between diarrhea and constipation. These extreme stool consistencies can sometimes even occur within the same bowel movement.
Intestinal pain can result as material in one section of the gut passes through slowly while material in another section passes through quickly. These actions, occurring simultaneously, can result in alternating between constipation and diarrhea, sometimes within the same bowel movement. In addition, prolonged contractions of the bowel might prevent the normal passage of air, triggering bloating, belching, and flatulence. Bloating could become so severe that clothing feels tighter and abdominal swelling becomes visible to others.
Pain manifests in many ways with IBS. It can be ongoing or episodic, come on sharply and then resolve rapidly, occur occasionally or frequently, and move from one location in the bowel to another very quickly. Digestive pain often occurs following a meal and can last for hours. Those who have IBS tend to have a quicker and more intense reaction to digestive tract pain stimuli than do those who do not have IBS.
Symptoms occurring outside of the digestive tract, possibly related to IBS, can include sleep disturbances, fibromyalgia, back pain, chronic pelvic pain, interstitial cystitis, temporomandibular joint disorder, post-traumatic stress disorder, and migraine headaches. Female patients who have IBS have also reported discomfort during sexual intercourse (dyspareunia).
Patients who have IBS-D or IBS-A often feel unable to engage in work or social activities away from home unless they are certain that there are easily and quickly accessible bathroom facilities available. Patients with IBS-C are often in such pain that they find even slight body movements uncomfortable. Pain and frequent bowel movements or preoccupation with an inability to eliminate stool may make school, work, and social situations difficult.
Those who suffer with IBS might experience some psychological symptoms. These include a diversity of strong emotions related to the condition that range in intensity, including anxiety, depression, loss of self-esteem, shame, fear, self-blame, guilt, and anger. Fortunately, psychological management of IBS can often help reduce these symptoms.
As the symptoms of IBS are varied and there are no organic tests to determine specifically whether a patient has IBS, part of the diagnostic process is to rule out other known diseases. Typically, a physician takes the following steps to reach an IBS diagnosis:
Medical History: A physician reviews the patient’s medical history, considering bowel function pattern, the nature and onset of symptoms, the presence or absence of other symptoms, and warning signs that might indicate some other diagnosis. It is important to note what symptoms do not relate to IBS and these include weight loss, blood in the stool, and fever. If the need to defecate wakes you from your sleep, you should report this to your physician as it is not typical of IBS and could have other implications.
Bowel pain and uterine/ovarian pain may be difficult to distinguish from each other, so gynecological conditions might delay or confound an IBS diagnosis in women.
Physical Examination: During a physical evaluation, the bowel may have involuntary jerky muscular contractions (spastic) and seem tender, although the patient’s physical health usually appears normal in other respects.
Investigative Testing: A physician might request tests to rule out other possible diseases. In performing a scope, physicians view the intestinal tract with an instrument that enters the body via the mouth (gastroscopy) or the anus (colonoscopy/sigmoidoscopy). The scope is made of a hollow, flexible tube with a tiny light and video camera.
The physician may also request routine blood and stool tests to rule out known organic diseases. Some symptoms of celiac disease overlap those of IBS, so a family history of this disease might be a reason to test for it.
A physician makes a diagnosis of irritable bowel syndrome after taking these steps, and after considering the nature of the patient’s symptoms in relation to the information detailed in the Thirty-Second IBS Test.
The cause of IBS has not been determined. It primarily presents as a functional disorder with altered patterns of intestinal muscle contractions. While IBS is chronic and painful, there is no evidence for a relationship between this disorder and an increased risk of more serious bowel conditions such as inflammatory bowel disease or colorectal cancer.
Although not proven, theories exist as to factors that influence IBS symptoms, including:
- neurological hyper-sensitivity within the gastrointestinal (enteric) nerves
- physical and/or emotional stress
- dietary issues such as food allergies or sensitivities, or poor eating patterns
- antibiotic use
- gastrointestinal infection
- bile acid malabsorption
- the amount or pattern of physical exercise
- chronic alcohol abuse
- abnormalities in gastrointestinal secretions and/or digestive muscle contractions (peristalsis)
- acute infection or inflammation of the intestine (enteritis), such as traveller’s diarrhea, which may precede onset of IBS symptoms
The gastrointestinal (GI) system is very sensitive to the hormone released when one is excited, fearful, or anxious (adrenaline) and to other hormones as well. Changes to female hormone levels also affect the GI tract, so IBS symptoms may worsen at specific times throughout the menstrual cycle. Since hormones play a role in the transit time of food through the digestive tract, this might account for the predominance of IBS in women, although the evidence is still lacking.
It is important to note that since there is no definitive proof of the source of IBS, many promoted potential ‘causes’ and advertised ‘cures’ of this syndrome are simply speculation.
The gastrointestinal tract is an extremely complex system, influenced by many nerves and hormones. It is clear that both the secretions and motility of the intestine are affected by the type of food eaten, the frequency and environment of eating, and by various medications.
The most important aspect of IBS treatment is for patients to understand the nature of their unique symptoms and any potential aggravating or triggering factors. Also helpful is recognizing that it may take time before bowel function returns to a more normal state.
Dietary and Lifestyle Modifications
The bowel responds to how and when a person eats, so it is important to eat regular, well-balanced, moderately sized meals rather than erratic, variable meals. Occasionally, IBS symptoms improve by allowing sufficient time for regular eating and bathroom routines.
Some IBS patients report that dietary fats trigger symptoms, as can the food additive MSG (monosodium glutamate). Some find symptoms worsen when consuming large quantities of liquids with meals. Others find that cooking vegetables and fruits lessens IBS symptoms, compared to when eating them raw. Particularly if the predominant symptom is diarrhea, an IBS patient should avoid or decrease consumption of gastrointestinal stimulants such as caffeine, nicotine, and alcohol.IBS patients do not necessarily produce more gas than the non-IBS population, but their intestines may be extra sensitive to the passage of gas. Things that might help include reducing ingestion of swallowed air, which is the major source of intestinal gas, and avoiding large quantities of gas-producing foods. To decrease swallowed air, avoid gum chewing, gulping of food, washing food down with liquids, and sipping hot drinks. Poor-fitting dentures, a chronic postnasal discharge, chronic pain, anxiety, or tension may also contribute to increased air swallowing. For more information, ask about our Intestinal Gas pamphlet.
Other IBS patients have found lower carbohydrate diets helpful. A proposed therapy for IBS, called the low FODMAP diet, is increasing in popularity in North America. FODMAP is an abbreviation for Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols. These are the names of poorly digested carbohydrates, which travel into the large intestine where they are fermented by the resident bacteria. For many individuals, these foods do not cause any problems, but some who have IBS find that these foods worsen their symptoms. The diet involves not eating specific foods for 6 to 8 weeks to see if symptoms subside. If they do, then the person can slowly reintroduce FODMAPs into the diet to a tolerable limit. FODMAPs are in many foods so removing them from your diet can increase your risk of nutritional deficiencies. While the results of studies conducted on the low FODMAP diet suggest its promise as a possible management approach for some IBS patients, further research is required, and it does not help everyone.
By keeping a food intake diary and noting any adverse reactions, you can quickly identify and remove problematic food from your diet and determine an approach that works best for you. Be sure to consult a registered dietitian before eliminating any food group long-term. For more information on food groups and a balanced diet, consult Canada’s Food Guide, available from Health Canada.
An important step in controlling the symptoms of IBS is to increase dietary fibre from plants, which the human body cannot digest on its own. The fibre content of foods stays the same with cooking, although this process may change its effect within the gut. When considering fibre, it is important to look at both the fibre content of foods and the type of fibre (insoluble or soluble).
Gradually increase dietary fibre, allowing your body to adjust to the change, making sure to increase the amount of water you drink. This will minimize any adverse effects that may arise from a sudden dietary change. Your physician or dietitian may recommend the addition to your diet of one of the many commercially prepared, concentrated fibre compounds on the market, such as Benefibre®, or Metamucil®.
Insoluble fibres increase stool bulk, increase colonic muscle tone, and accelerate the transit time of gastrointestinal contents, thus relieving mild constipation.
Water-insoluble fibres include:
- lignin (found in vegetables)
- cellulose (found in whole grains)
- hemicellulose (found in cereals and vegetables)
Soluble fibres form gels when mixed with water, making the bowel contents more sticky and resistant to flow (viscous) so that food stays in the digestive tract longer. This is important for people who suffer from diarrhea.
Some examples of water-soluble fibres include:
- pectins (e.g., apples, bananas, grapefruit, oranges, strawberries)
- gums (e.g., cabbage, cauliflower, peas, potatoes, oats, barley, lentils, dried peas, beans)
It is important to note that for some IBS-D patients, a diet excessively high in bran fibre might trigger more frequent diarrhea, while other types of fibre could still be helpful. Consult your physician or dietitian if you have any questions regarding fibre in your diet.
Separate from the central nervous system, the gut has its own independent nervous system (enteric), which regulates the processes of digesting foods and eliminating solid waste. The enteric nervous system communicates with the central nervous system and they affect each other. Many IBS patients report high levels of stress, which might relate to factors such as poor sleep habits, working too hard, and the excessive use of caffeine, alcohol, and/or tobacco. IBS is not a psychological disorder, even though stress, depression, panic, or anxiety, may aggravate bowel symptoms. Proper exercise and rest can help reduce stress and positively influence IBS symptoms.
Psychological treatments may augment medical treatment, including relaxation training, time management, lifestyle changes, and cognitive restructuring. For more information, see our page on stress management.
The pelvic floor consists of muscles that help control defecation. IBS patients might have pelvic floor incoordination (dyssynergia/anismus). A physiotherapist with training in pelvic floor rehabilitation can conduct a thorough examination which may include a digital vaginal exam (for women), a digital rectal exam, observation and touching (palpation) of the perineum and abdominal wall, and electromyographic (EMG) biofeedback assessment. The goal of physiotherapy treatment is to develop the ability to relax the pelvic floor completely while simultaneously allowing gentle propulsive forces from deep abdominal muscles to evacuate the bowel fully. Physiotherapy might also help those who have diarrhea-predominant symptoms and experience bowel urgency and/or incontinence of watery stools. Check with your regional physiotherapy association to find a registered physiotherapist who has incontinence or pelvic floor training.
Researchers are continuing to look for new medications to treat IBS symptoms and your physician may prescribe products other than those listed. See medication chart below.
Since IBS presents primarily as a motility disorder, physicians usually prescribe drugs that target this condition. These agents, pinaverium bromide (Dicetel®), and trimebutine maleate (Modulon®), help to restore the normal contraction process of the bowel. They are most effective when taken for a full course of treatment and are not designed for immediate symptom relief or sporadic, intermittent use. Dicetel® is a gastrointestinal selective calcium antagonist, which works by blocking calcium uptake, and helps to synchronize the muscle movement of the bowel. Dicetel® treats all IBS symptoms of abdominal pain, bloating, constipation, and diarrhea in both women and men. Modulon® regulates motility by moderating kappa opiate receptor affinity and slows the movements of the bowel.
The following anti-diarrheal medications work by altering the muscle activity of the intestine, thereby slowing transit time:
- non-narcotic loperamide (Imodium®), which is also useful in fecal incontinence as it helps tighten the anal sphincter
- narcotic agents such as diphenoxylate (Lomotil®), codeine, tincture of opium and paregoric
- anti-spasmodic agents that block the transmission of nerve impulses, such as hyoscyamine sulfate (Levsin®), dicyclomine (Bentylol®), and hyoscine butylbromide (Buscopan®)
Anti-diarrheal drugs are generally not helpful long-term for those with IBS-A, and those who have IBS-C should not take them.
Some products can ease both diarrhea and constipation by bulking up the intestine, helping it to function better by regulating content transit time and stool consistency. Included are various bulk-formers, which adjust stool looseness and frequency by soaking up (binding to) water. Commercial fibre products with these benefits come in the forms of bran cereals, wafers, ispaghula husk, psyllium seed (Metamucil®), guar gum (Benefibre®), and inulin (Simply Clear). Remember to go slowly when adding these products to the diet and increase your water intake. Check the labels carefully, or consult a pharmacist to ensure the product you obtain will help your symptoms.
A guanylate cyclase-C agonist, linaclotide (Constella®), is now available for the treatment of irritable bowel syndrome with constipation. In clinical trials, Constella® showed statistically significant improvement in bowel habits, (including spontaneous bowel movements, complete spontaneous bowel movements, stool consistency, and straining), and abdominal symptoms, (including abdominal pain, bloating, abdominal discomfort, and percent of abdominal pain-free days) during the 26-week treatment period. Diarrhea was the most common side effect.
Other medications could offer some symptom reduction by working in different ways. For example, pancreatic enzymes such as Cotazym®, Creon®, Pancrease®, Ultrase®, and Viokase® may also work in a small number of cases to relieve symptoms of IBS by facilitating digestion. Bile salt binders such as cholestyramine (Olestyr®, Questran®) help against diarrhea, and are especially useful when transit time in the small intestine is very fast. Anti-depressants and anti-anxiety medications in low doses may help the enteric nervous system to relax as well as relieve pain and improve disordered sleep. Iberogast®, a medicine consisting of plant extracts, may help relieve IBS symptoms. The effectiveness of these agents differs between individuals.
Probiotics are the friendly, living microorganisms (bacteria and yeasts) usually living within the human gut that are essential for maintaining normal gastrointestinal function. These probiotics are often referred to as gut flora, although this term is not strictly correct as flora pertains to plants, not microorganisms. Some research links the origin and development of various chronic intestinal disorders (pathogenesis) to disturbances in the gut flora itself or to the body’s inability to interact properly with the flora. These results have encouraged scientists to develop new ways of modifying the complex intestinal ecosystem as a means of therapy and prompted the medical community to step-up its efforts to reduce the use of antibiotics, since these products can disrupt the natural gut microorganism balance.
While probiotics have a particular appeal in treating IBS, the treatment challenges are plentiful. Many commercial products fail to contain the quantity of live bacteria claimed on their labels. Additionally, harsh stomach acids kill most probiotics (which food producers/manufacturers add to foods such as yogurt) before they reach the colon, where they need to be alive to do their job. If you want to add probiotics to your diet, it is likely you will not find sufficient quantities in yogurt to improve your digestive health, as some marketers might claim.
Some commercial products actually do contain sufficient quantities of probiotics and they have special formulations to get them past the acidic stomach environment. Emerging science suggests that specific probiotics are effective only for particular medical conditions. We urge consumers to ensure that the probiotic they are purchasing is a proven treatment for their medical condition.
The true potential benefits and risks of probiotics in GI health have yet to be determined, but research in this innovative field is advancing quickly. Examples of Natural Health Products containing bacterial probiotics for treating the symptoms of IBS are TuZen® (Lactobacillus plantarum 299V), which has demonstrated effectiveness in relieving abdominal pain, bloating, constipation, and diarrhea, and Align™ (Bifantis® Bifidobacterium infantis 35624)addressing symptoms such as abdominal discomfort, gas, and bloating.Another example is Florastor® (Saccharomyces boulardii lyo) the digestion-friendly yeast (found naturally on the skin of lychees and mangosteens in Indochina), which has demonstrated effectiveness in regulating the number and consistency of stools. BioGaia® Drops (Lactobacillus reuteri), are effective in early infancy to reduce episodes of colic. As our understanding of the intricate milieu of microorganisms within the human gut deepens, we may be able to customize probiotic therapies as significant and effective IBS treatments.
Medication and Treatment Charts
|Analgesics to reduce abdominal pain:||Anti-depressant:||Anti-spasmodics:||Enteric opioid:||GI selective calcium antagonist:||Guanylate cyclase-C agonist:||Other:|
|preferred choice is acetaminophen (Tylenol®) without codeine||e.g., amitriptyline||hyoscyamine sulfate (Levsin®), dicyclomine HCl (Bentylol®), propantheline bromide, hyoscine butylbromide (Buscopan®), belladonna alkaloids, phenobarbital||trimebutine maleate (Modulon®)||pinaverium bromide (Dicetel®)||linaclotide (Constella®)||Iberogast®, Lactobacillus plantarum 299V (TuZen®), Bifantis® Bifidobacterium infantis 35624 (Align™)|
Bloating (Abdominal Gas)
|Antiflatulen:||GI selective calcium antagonist:||Guanylate cyclase-C agonist:||Motility agents:||Other:|
|simethicone (e.g., Gas-X®) , other agents (e.g., Diovol®), antacids/anti-flatulent (e.g., Maalox®)||pinaverium bromide (Dicetel®)||linaclotide (Constella®)||domperidone maleate||peppermint oil, Iberogast®, Lactobacillus plantarum 299V (TuZen®), Saccharomyces boulardii lyo (Florastor®), Bifantis® Bifidobacterium infantis 35624 (Align™), and Lactobacillus reuteri (BioGaia® Drops) for infant colic (which is generally associated with abdominal gas)|
|Buling agents:||GI selective calcium antagonist:||Guanylate cyclase-C agonist:||Mucosal protective agent:||Osmotic laxatives:||Other:|
|bran, psyllium seed, or ispaghula husk derivatives (e.g., Metamucil®), calcium polycarbophil (Prodiem®)||pinaverium bromide (Dicetel®)||linaclotide (Constella®)||misoprostol (Cytotec®)||magnesium hydroxide (milk of magnesia), lactulose||Iberogast®, Lactobacillus plantarum 299V (TuZen®)|
|GI selective calcium antagonist:||Anti-diarrheal (group 1). Alter muscle activity of the intestine, slowing down content transit:||Anti-diarrheal (group 2). Heterogeneous bulk formers that adjust stool looseness and frequency by soaking up (binding to) water in the bowel:||Other:|
|pinaverium bromide (Dicetel®)||Anti-spasmodics: hyoscyamine sulfate (Levsin®), dicyclomine (Bentylol®), propantheline bromide, hyoscine butylbromide (Buscopan®), belladonna alkaloids, phenobarbital
Narcotic anti-diarrheal agents: diphenoxylate-atropine sulphate (Lomotil®), codeine, tincture of opium, paregoric
Non-narcotic anti-diarrheal agent: loperamide HCl (Imodium®)
|Bile salt binder: cholestyramine resin (Olestyr®, Questran®)
Bulking agents: bran, psyllium seed, or ispaghula husk derivatives (e.g., Metamucil®) guar gum nulin (e.g., Benefibre®, Metamucil®, Simply Clear)
|Iberogast®, Lactobacillus plantarum 299V (TuZen®), Saccharomyces boulardii lyo (Florastor®)|
Over time, with understanding and faithful adherence to an individualized treatment plan, many patients with irritable bowel syndrome can look forward to a significant improvement in their condition. In fact, statistics show that approximately 10% of IBS patients get better each year, although a different 10% will develop the condition, keeping the percentage of people in the population with IBS at any given time fairly consistent.
IBS remains a condition that can seriously compromise an individual’s quality of life and, regrettably, not everyone with IBS will become symptom-free. In most cases, treatment will be ongoing and individualized to meet the specific patient needs and improve daily function.
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